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Silvitra: A Pharma Perspective Leave a comment

CharacteristicDescription
Active IngredientsSildenafil 100 mg, Vardenafil 20 mg
FormTablet
IndicationErectile Dysfunction
DosageAs directed by a healthcare provider
Visit Silvitra Site

Silvitra is a combination medication used to treat erectile dysfunction in men. It combines the therapeutic effects of Sildenafil 100 mg and Vardenafil 20 mg, two potent phosphodiesterase type 5 inhibitors. These drugs work together to enhance the natural response to sexual stimulation.

Pharmacokinetics

Silvitra combines Sildenafil 100 mg and Vardenafil 20 mg, which are rapidly absorbed. Both components reach peak plasma concentrations within an hour. Their bioavailability is approximately 41% and 15%, respectively. The presence of food can delay absorption, although it does not reduce efficacy. The drug’s half-life is about four to five hours, allowing effective plasma levels for the required duration. It is metabolized in the liver, primarily by CYP3A4.

The pharmacokinetics of Silvitra require consideration of liver function, as impaired hepatic function can alter drug clearance. Monitoring renal function is also critical, particularly in patients with renal insufficiency. The plasma binding is high, around 96% for both compounds, ensuring a prolonged effect. Steady-state concentrations are achieved within a few days of regular dosing.

Mechanism of Action

The dual-action of Silvitra is due to its components, Sildenafil 100 mg and Vardenafil 20 mg. These inhibitors block the enzyme phosphodiesterase type 5 (PDE5), preventing the breakdown of cyclic guanosine monophosphate (cGMP). This leads to smooth muscle relaxation in the corpus cavernosum, allowing increased blood flow to the penis. The result is enhanced erectile function in response to sexual arousal.

Silvitra enhances the effects of nitric oxide released during sexual stimulation. The increased cGMP levels prolong vasodilation, which is crucial for sustaining an erection. It is important to note that Silvitra only works in the presence of sexual stimulation and does not increase sexual desire.

Silvitra Precautions

Before initiating treatment with Silvitra, a thorough medical evaluation is essential. Consider cardiovascular status, as sexual activity poses a risk for those with heart conditions. Caution is advised for patients with anatomical penile deformation. Avoid concurrent use with nitrates or nitric oxide donors due to the risk of severe hypotension.

Alcohol consumption should be minimized, as it can exacerbate side effects. Caution is also advised for individuals with predispositions to priapism or those using other PDE5 inhibitors. A complete list of medications and supplements should be discussed with a healthcare provider to prevent interactions.

Silvitra Storage

Store Silvitra at room temperature, between 15°C and 30°C (59°F and 86°F). Keep the tablets in their original packaging, protected from moisture and light. It is vital to keep this medication out of reach of children and pets. Discard any expired or unused tablets responsibly.

Do not store Silvitra in the bathroom or places with high humidity. A stable environment ensures that the drug maintains its efficacy and safety. Proper storage extends the shelf life of the medication and preserves its therapeutic effects.

How to Cope with Side Effects of Silvitra

Common side effects include headaches, flushing, and dizziness. Stay hydrated and rest if headaches occur. Use over-the-counter pain relievers if necessary. Flushing typically resolves on its own. If dizziness happens, avoid sudden movements and rest until it subsides.

Seek immediate medical attention for severe reactions like chest pain, a prolonged erection, or sudden vision loss. A healthcare provider should monitor any persistent side effects. Adjustments to dosage or medication may be necessary.

Where to Buy Silvitra Online

Silvitra can be purchased from licensed online pharmacies. Ensure the pharmacy is reputable and requires a prescription. Buying medications from uncertified sources can lead to receiving counterfeit products.

Online platforms may offer the convenience of home delivery and competitive pricing. Verify the authenticity of the site and look for customer reviews. This step helps ensure you are getting a legitimate and safe product.

Key InformationDetails
Onset of Action30 to 60 minutes
Duration of EffectUp to 6 hours
Prescription RequiredYes
  • Consult a healthcare provider before using.
  • Report any severe side effects immediately.
  • Adhere strictly to prescribed dosages.
  • Verify online pharmacy authenticity.

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